Heat oven to 350°F.
Line 13x9-inch pan with foil, with ends of foil extending over sides; spray foil with cooking spray. Mix flour, 1/4 cup granulated sugar and brown sugar in medium bowl until blended; cut in butter with pastry blender or 2 knives until mixture resembles coarse crumbs. Stir in oats and nuts.
Reserve 1 cup oat mixture; press remaining onto bottom of prepared pan. Bake 15 min. Beat cream cheese, remaining sugar, eggs, pumpkin and spice with mixer until blended. Pour over crust; sprinkle with reserved crumb mixture.
Bake 25 min.; cool 10 min. Use foil handles to remove dessert from pan. Place on wire rack; cool completely.